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Issue
#5
Oxymetholone
By
Robi Babic
The following
article was motivated by some of the trends currently manifested
in our sport. It seems that success (competitive or otherwise) in
the sport is always associated with enormous use of various anabolic
agents, especially the more exotic ones. One such substance is oxymetholone
(trade name Anadrol, Anapolon, Hemogenin).
The usual gym
intro goes like this: it is the strongest oral anabolic steroid,
expected gains border on science fiction (a pound a day or more),
side effects are serious (possible liver cancer), and it is most
certainly necessary for competitive success (it literally creates
champion bodybuilders). Such statements are more or less poppycock.
First, let's
explore its legitimate medical use. Oxymetholone was originally
used by patients suffering from anemia. It stimulates the production
of erythropoietin, and is extremely effective, although relatively
toxic. It is the only steroid which is conclusively linked with
cancer. While available, it was also very cheap. In recent years,
it has become rather obsolete, as a new drug named EPO was developed
for treating conditions related to anemia. EPO is a favorite of
professional bicyclists, and is also used by high-level amateur
and professional bodybuilders during contest preparation. Pharmaceutical
companies prefer to distribute (one might even say PUSH) EPO rather
than oxymetholone, as the former generates greater profits. So,
the legitimate production of oxymetholone has dropped considerably,
in some parts of the world it has ceased altogether. This situation
has created problems for a lot of athletes, and the lack of availability
is probably a causative factor behind the hype surrounding oxymetholone.
Athletes (recreational
and professional) usually praise substances that are not readily
available. In most cases, however, the hype does not hold water.
Yes, these hard-to-find drugs do produce results, but laws of supply
and demand makes them very expensive. Then there is a problem with
fakes. High demand exceeds supply by far, so the floor is set for
crooks to make a buck and naïve, mostly recreational athletes make
it even easier for them to succeed in their dirty job.
Some of my acquaintances
are perfect examples of such trends: one competitive bodybuilder
cannot afford growth hormone, so its absence from this guys stack
is the reason why he cannot make a breakthrough in his development.
Another one uses everything he can get his hands on. He went even
so far and gained 28 kilograms (62 pounds) in 32 days (against my
advice - using shotgun approach), and then had the nerve to call
for my advice when the side effects became too serious. Very few
people can endure such rapid weight gain without ill effects. Needless
to say, his gain was mostly water and upon cessation of the cycle
(if it can be called a cycle), his weight quickly evaporated. This
just goes to show you that FAST is going to get you nowhere. Unquestionably,
anadrol is an effective steroid for sheer mass, but it is not my
top choice for several reasons. First, it is not suitable for stacking.
Anecdotal reports suggest that when anadrol is used on its own (monotherapy),
side effects should not cause substantial problems (unless you are
genetically sensitive individual). There is the flu-like effect
and water retention (possible hypertension), maybe some acne, headaches,
hair thinning, and possible gynecomastia but all these side effects
are cosmetic and do not severely affect the health of the user.
The picture changes once anadrol is part of a stack. Liver function
is usually greatly compromised (hepatitis, jaundice), and if the
individual decides to stay on the compound for extended periods
(or has high frequency of using the compound), permanent pathological
liver changes are possible, including liver cancer (hepatocarcinoma).
Water retention related hypertension is increased, and risk of gynecomastia
is drastically increased as well. All these side effects usually
accompany stacks containing anadrol, sometimes regardless of the
cumulative dosage of steroids per unit of time (this phenomenon
is odd, as the side effects seem to be of similar intensity, using
either 500mg of steroids per week, or 2000mg or more of steroids
per week, as long as oxymetholone is part of the stack). Consequently,
I do not suggest that my clients use anadrol, at least not in stacks.
It also has to be pointed out that anadrol should not be in the
drug arsenal of the recreational bodybuilder, this drug has significant
enough health risk that it should be reserved for top bodybuilders
and athletes. Forget reports that Chris Duffy (in his pre-porn days)
used 10 anadrols daily, on top of 2000mg testosterone weekly, in
addition to his purported massive use of clenbuterol. Such quantities
are vastly exaggerated (or he is a genetic miracle, or had extremely
well designed all-round protection program against side effects
while using such stack, or both).
Another problem
I see with anadrol is its availability. A healthy amount of mysticism
is wrapped around anadrol. Most athletes that do not have the access
to the drug firmly believe that should they somehow attain a sufficient
quantity of the drug, their bodybuilding progress would change overnight.
Often times, failure to acquire thus drug is the reason they attribute
their lack of meaningful progress in their physiques. Most of the
oxymetholone on the black market is fake anyway. And even if one
is lucky enough to discover a reliable source of legitimate drug,
its price is hardly worth its effects. Yes, you will gain mass,
but not a pound or more daily for the first few weeks on the drug
(as reported in several popular publications). The same results
can be attained by using injectable testosterone in upwards of gram
quantities weekly, and injectable testosterone, even a dosages of
1 g a week, if far less toxic than using anadrol.
Lets discuss
anadrols strength. Oxymetholone has very poor receptor binding ability,
so it has to be manufactured in 50mg per unit (tablet) to achieve
the desired therapeutic effect. A comparison (milligram per milligram)
of oxymetholone with methandrostenolone (DIANABOL) would reveal
a similar strengtht and anabolic effect per each milligram. Keep
in mind, that for every tablet of anadrol (50mg), you would have
to ingest 10 tablets of dianabol (5mg). This quantity probably negates
any financial benefit on the part of dianabol, but at least accessability
of dianabol is not a problem. At such quantity side effects of dianabol
would be comparative to that of anadrol. On a mg per mg basis, Another
problem with anadrol is its yo-yo effect (fluctuations in bodyweight).
Once the compound is discontinued, the weight-loss is rapid, affecting
the psychlogical as well as physical status of the trainee. This
in turn drives the athlete to prematurely engage in another unnecessary
or counterproductive cycle.
To avoid such
problems, one should implement a strong injectable androgen (usually
testosterone), upon cessation of monotherapy with anadrol. The testosterone
should then be replaced with a high dose mild anabolic in conjunction
with heavy anti-estrogen therapy and finally, its dosage should
then be tapered off. This strategy will ensure that most of the
gains will be kept in transition and consequent "off" period.
Questions
and comments:
r_babic01@yahoo.com
THE AUTHOR
OF THIS ARTICLE DOES NOT ENDORSE THE USE OF PHARMACOLOGICAL SUBSTANCES
FOR ERGOGENIC PURPOSES. THE ARTICLE IS FOR EDUCATIONAL PURPOSES
ONLY. THE PRESENTED VIEWS ARE THAT OF THE AUTHOR AND SHOULD NOT
BE CONSTRUED AS A MEDICAL ADVICE.
ABOUT THE
AUTHOR: I HAVE NO FORMAL EDUCATION IN THE FIELD OF PHARMACOLOGY
AND MEDICINE. I HAVE, HOWEVER, WORKED FOR SEVERAL YEARS IN PHARMACIES
AND HOSPITALS (AS PART OF TECHNICAL STAFF), ENABLING ME TO STUDY
THE MOST RECENT ADVANCES OF MODERN PHARMACOLOGY AND MEDICINE BY
HAVING ACCESS TO VARIOUS HARD-TO-FIND ACCURATE LITERATURE. I AM
ALSO A STEROID USER WITH SEVERAL YEARS OF EXPERIENCE.
Copyright
1999 Jason Meuller and Anabolic Extreme. This material may not be
copied, reproduced, or transmitted without the express written permission
of the copyright owners.
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