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November 03, 2000
Issue #19




 

 

                      Supplementing the Extreme
                                
                                          by Derek Cornelius

Question:  A guy at my gym told me about how great HMB is…that it’s a wonder supplement, a potent anabolic muscle builder, and a compound that’s as strong as the anabolic steroid nandrolone decanoate.  The problem is that this guy is really small and never seems to make any gains.  What’s the deal with HMB?

Answer:  Your “friend” in the gym has obviously been reading old literature which touts HMB as nearly the greatest muscle-building compound ever developed.  The hype surrounding this compound culminated with the statement that HMB makes a person feel as if he was taking the anabolic steroid Deca Durabolin (nandrolone decanoate).  We now know that this is nonsense and that HMB does very little in comparison to any anabolic steroid, including nandrolone decanoate.  To be fair, HMB does have some research behind it which shows that it might be effective in promoting a positive nitrogen balance (which, in turn, may accelerate muscle growth).  The problem is that many compounds look good or even great on paper—human growth hormone for example—but produce little or no significant results in the real world.  This is exactly what we see with HMB!  Indeed, there are some studies showing promise but in the real world this compound does nearly nothing for muscle growth.  Compounding the problem is the fact that large quantities must be taken which also makes it very expensive.  My advice is to stay away from HMB and instead invest your money into one of the highly effective steroidal nutrients such as Isoinokosterone or Methoxivone.  Currently, our extensive research lab is working on some HMB derivatives which we hope will solve many of the problems that currently plague HMB.  I will keep you updated on this as we make progress.   

I strongly recommend to everyone to be smart when buying supplements.  Most companies just want to hype, and like and thus cheat you out of your money.  Be smart!  If a company makes outrageous claims, you can be almost certain that they are trying to rip you off.  You’ve heard it before…if it sounds too good to be true then it usually is.  In this industry, it always is!!!   

Question:  I’m a regional champion in powerlifting!  It is more than a hobby to me; it is a passion.  Simply, I love every aspect of the sport.  I’ve learned so much from Anabolic Extreme.  From training to nutrition advice to drug usage, AE has done more for me than any other publication.  I’ve been enthralled with the many articles on supplementation of late.  I’ve been using some of the new powerful supplements now available such as Isoinokosterone and Ipriflavone and have made considerable gains in my lifts such as the bench and squat.  The problem is that the extra poundage is causing some of my joints to hurt.  What can I do to repair/alleviate my joint problems?

Answer:  Unfortunately, there is no single specific treatment that will cure or even alleviate all joint problems.  There can be many causes for joint pain including tendon inflammation, dry joints, calcified joints, and connective tissue damage/inflammation.  If you have some simple and minor tendon inflammation, an NSAID such as Ibuprofen might do the trick until your tendons develop and become strong enough to handle the weight.  At best, this should only be a temporary treatment as long term use of NSAIDs have been shown to worsen joint health.  I feel that the absolute best approach to maintaining utmost, pain-free joint health is a multifaceted approach which has, at its backbone, preventative care instead of therapeutic care.   

Currently in the U.S., the medical establishments’ approach of taking care of your body is strictly therapeutic.  Their motto is to leave it alone unless some problem occurs.  Only at this point will they recommend a treatment—this usually being only to deal with the symptoms and not the actual problem.  What I suggest is to supplement your diet with many different compounds with different modes of action that have been shown in medical studies to not only alleviate joint pain but to actually build up and repair the joints.   

Two of the best compounds to take are glucosamine hydrochloride and chondroiten sulfate.  These mucopolysaccharides have been studied extensively and have been shown to not only alleviate joint pain but to also increase joint health.  Both of these compounds  help produce substances needed for the formation of healthy connective tissue.  In particular, glucosamine is the critical building block of proteoglycans.  These proteoglycans are large protein molecules that act like a sponge to hold water—giving connective tissues elasticity and cushioning effects which provide a buffering action to help protect against impacts that could otherwise cause damage.  The proteoglycan stimulating effect also increases the amount of protective lubricating substances like synovial fluid which cushions and keeps our joints moving friction and pain free.  Finally, chondroiten, unlike glucosamine, has the ability to protect existing cartilage from prematurely breaking down by inhibiting enzymes that normally destroy cartilage.  I am a firm believer in taking these two compounds on a daily basis as part of a rigorous program of maintaining good joint health. 

Glucosamine and chondroiten are incredibly effective compounds but really only affect the actual joint unit.  Although they might help slightly, they are probably not going to be highly efficacious for symptoms of tendon inflammation (tendonitis).  This is probably what happens when someone starts lifting higher weights—a greater stress is placed on the tendons which causes an inflammation.  Sometimes lifters experience this on a chronic basis even if they lift light weights.  To combat this, an antiinflammatory compound should be used.  Again, an NSAID could be taken but this is at best ideal in temporary situations.  A better approach is to supplement your diet with potent and naturally occurring antiinflammatories like boswellic acid.  This compound is extracted from boswellia serrata, a tree growing in India.  In studies, this compound has been shown to be just as effective as the NSAIDs Ketoprofen and Phenylbutazone without the nasty side effects such as gastrointestinal problems and joint deterioration.  Boswellic acid is ideal for inflammatory conditions such as tendonitis.  It is also ideal for other types of joint inflammation that might not be taken care of with glucosamine and chondroiten.

To summarize, I recommend everyone to take glucosamine and chondroiten (at the absolute minimum glucosamine) on a daily basis and to take a natural antiinflammatory such as boswellic acid when direct antiinflammation is needed such as in cases of tendonitis.  Again, compounds like Ibuprofen can be used but take these sparingly and only temporarily.


Question:  I know most of your readers are probably men, but I’m a happy female reader.  I guess I’m just hardcore and thrilled with all of the cutting-edge information that is contained every week in your “pages”.  My question is that I’m 25 years old and I can’t stand white skin.  I’ve been tanning since I’ve been 16.  I don’t know if the sun is doing it, but I’m getting little lines around my eyes.  What is causing this and what can I do about  it?  Thanx for all the help! 

Answer:  Actually, your question is right up my alley.  A pharmaceutical lab out of the middle east has been working on a tanning product that will be truly revolutionary.  Basically, you will be able to get an extremely dark tan by only tanning a few times.  Until this product comes out, I can only recommend a very healthy supplement that will benefit you in many ways.  First, it will reduce the damage to your skin and second it will make you look like you have a very nice tan…especially if you already have a some natural color to your skin.  The only problem is it can make your palms look a little orange if you take too much.  For your benefit, I have provided an article that I wrote a while ago on this supplement.

 
                       CANTHAWHATSIN?

                                                
by Derek Cornelius 

 
That's canthaxanthin--pronounced can tha zan thin.  Although it sounds like a product that CAN make you THIN, canthaxanthin has nothing to do with fat loss or making you slender.  It does, however, have everything to do with keeping your skin healthy and making it a beautiful color.  This is an extremely important topic right now considering that the warm months are just around the corner and many of you will be scrambling to the nearest tanning bed to get that perfect, beautiful, bronze tan.  I have to admit that a good tan looks nice but one TINY little problem surrounds its achievement—the damaging effects of ultraviolet light (necessary for a tan) on the skin.  In fact, we now know that the single biggest reason for wrinkled skin—besides genetics—is the damaging effects of ultraviolet radiation. 

What we need is a tanning hero--a compound that will not only protect the skin from the damaging effects of the sun but will also give the skin a beautiful bronze color and will significantly enhance the appearance of any natural melanin pigmentation (i.e. a tan).  If you haven’t already guessed what the compound is then please meet canthaxanthin.  With a name like canthaxanthin, you might inherently be a little apprehensive about taking this compound but rest assured this supplement is extremely safe and very beneficial to your overall health.

Please allow me to properly introduce canthaxanthin by giving you a little background information on this amazing supplement.  Canthaxanthin is a well-studied carotenoid widely distributed throughout nature.  In order to understand the functions of canthaxanthin, a comprehension of the group of molecules called the carotenoids is necessary.  Carotenoids are biological pigments that are both the coloring of living organisms and the necessary molecules needed for important metabolic reactions.  They are distributed ubiquitously in leaves, flowers, fruits and roots of plants.  Furthermore, carotenoids are found in many animals, especially in marine invertebrates and in the brightly colored feathers of tropical birds.  All carotenoids that are found in animals are ultimately derived from plant or algae. 

The carotenoids are so widely distributed throughout nature because of their efficiency at protecting cells from various types of environmental damage.  Carotenoids are potent antioxidant molecules that protect plants from damage caused by singlet and triplet oxygen produced by ultraviolet rays and photosynthetic metabolism.  They are also free radical scavengers that prevent harmful uncontrolled oxidation chain reactions.  Finally, carotenoids protect plants from direct ultraviolet damage by absorbing high-energy ultraviolet photons and dissipating the energy along their hydrocarbon chains.  Mutant plants that contain no carotenoids soon die due to ultraviolet induced damage to the chlorophyll.  A similar situation occurs with carotenoids in animals.  These potent, colorful molecules act as ultraviolet light absorbers, antioxidants, and free radical scavengers thus protecting the animal’s DNA from genetic damage. 

The carotenoids consist of two main groups:  the carotenes and the xanthophylls.  Beta-carotene, which nearly everyone is familiar with, is the most common CAROTENE.  On the other hand, Canthaxanthin is a xanthophyll.  A difference worth noting is that beta carotene converts in the mammalian system to Vitamin A.  Canthaxanthin, as well as all xanthophylls, do not convert to any extent to Vitamin A.

Specifically, canthaxanthin is a naturally occurring carotenoid found in many different plants and animals.  It is the red coloring of many fruits, vegetables, and flowers, as well as some edible mushrooms.  It gives the pink hue of the feathers of brightly colored tropical birds such as flamingos and roseate spoonbills.  A few species of pink shellfish and some ocean crustaceans such as the red lobster contain this xanthophyll as does the pink flesh of salmon and the red spots on the skin of trout.  Besides being a red pigment, canthaxanthin functions as an ultraviolet photon absorber, a singlet and triplet oxygen quencher, and a free radical deactivator.  The incredible endurance of pink salmon on their long migrations to spawning grounds may be possibly due to the antioxidant qualities of the canthaxanthin that saturates their bodies.  They swim for thousands of miles in highly ionized oxygenated water without damage or death (conditions which would normally be fatal to a fish).

Now that I’ve given you all of the background information on carotenoids and canthaxanthin that you’ll ever want to know, I can hear everyone screaming at me to tell them how this can give them healthy, beautiful skin.  To answer this correctly, we must understand what happens to carotenoids when ingested in large quantities.  I am sure everyone has heard that if a person eats too many carrots their skin will turn yellow.  Indeed, this is true and the condition has been termed carotenemia.  Sometimes, this can appear to be jaundice, however, with jaundice the whites of the eyes become yellow, while carotenoids only color the skin and not the eyes.  Beta-carotene does a fine job of coloring the skin (actually the fat under the skin); however, the color is yellow--not very cosmetically pleasing!  A carotenoid that would color the skin a bronze color would be ideal--both for health and cosmetic reasons.

While beta-carotene is a yellow orange carotenoid, canthaxanthin is a deep red/brown.  Thus, when carotenemia occurs, a much darker, orange/red/brown color will appear.  On most parts of the body (except perhaps the palms and soles of the feet where it can appear orange) the coloring is very reminiscent of a tan.  Furthermore, I have found that canthaxanthin will enhance an actual tan by 2-3 fold.  Thus, one would have to lay in the sun or in a tanning booth much less to get the required tan.  Finally, the time spent in the ultraviolet rays would be much less harmful because the canthaxanthin would be quenching the free radicals and absorbing the photons!  Pretty cool, huh?

Are there any side effects to using canthaxanthin?  Yes, but they are absolutely harmless!  Because the body expels excess amounts that are not assimilated in the body, it can turn your stool a reddish color.  Since no one should be observing your stool anyway this definitely should not present a problem!  The only other side effect is an orangey coloration to the skin especially to the palms and soles of the feet.  This, however, can be controlled with dosage and by spending some time in the sun (or other form of ultraviolet light).  First, let me say that the orangey color usually appears with very excessive dosages and that cutting the dosage in half usually controls the phenomenon.  The other very effective way to put an end to the oranginess is to transform it to a nice bronze color.  The can be accomplished by the skin being exposed to ultraviolet light.  The neat thing about canthaxanthin is that it not only makes your skin appear tan when your skin has very little melanin in it but it changes its color when ultraviolet light hits it.  Fortunately, the changed color is a darker, deeper bronze.  Some things like cheese and wine become better with age; canthaxanthin becomes better with ultraviolet light! 

What are the most common misconceptions about canthaxanthin? 

 1.  Canthaxanthin stimulates melanin in the skin.  This is a lie and any company making these claims is defrauding the public.  Canthaxanthin has nothing to do with the skin's normal tanning process from ultraviolet ray stimulation.

 2.  Canthaxanthin will color the hair and eyes.  NOT TRUE!  Canthaxanthin only colors subcutaneous fat--thus giving the appearance of colored skin.

3.  Canthaxanthin causes liver damage.  FALSE--canthaxanthin is non-toxic.  The confusion may come from any of the two following reasons:

              a.  Excessive Vitamin A can cause Vitamin A Toxicity which could lead to liver damage.  The carotenoid beta-carotene is pro-Vitamin A and converts on demand into Vitamin A as the body needs it.  Unlike beta-carotene, Canthaxanthin is not pro-Vitamin A.

              b.  Liver failure can cause jaundice.  The coloration of the skin by carotenoids is not the same as being jaundiced.

If this stuff is so good, why don't we hear more about it?  Basically, we have our most wonderful and beloved FDA to thank!  Only one company in the U.S. manufacturers this compound and the FDA puts much pressure on this company to restrict its sale.  The FDA will not allow it to be sold as a tanning agent.  Thus, it must be sold as a food colorant/dye (how it is used in the food industry).  It is an arduous task to market such a compound and few companies are willing to spend the time and effort in doing so.  Canthaxanthin can be bought through some mail order companies in muscle magazines in the form of capsules--however it is usually very expensive.  The only other option that I know of is to search the Internet in hopes of a company that sells this compound cheaply.  Although it is expensive, canthaxanthin, in my opinion, is well worth the money.  It will not only assist your skin in staying young, supple and wrinkle free, but it will also make it very easy to achieve and maintain that beautiful bronze tan that you always wanted.

 

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