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October
2000 Methoxivone: What do you think when you hear the word “ANABOLIC?” For the few of us who truly know what this word represents, we start to salivate upon thinking about its reality. ANABOLIC means strong, hard muscles, Herculean endurance and a general sense of well being and confidence. Unfortunately, most of society sees ANABOLIC in a negative light. It’s like the four letter “A” word and “steroid” and you just might have a hoard of pretentious cops in your face calling you a criminal and telling you that “A” steroids are addictive, destructive, blah, blah, blah and just as bad as cocaine. Well, the situation is so bad that for the past several decades hardly any companies have spent a dime on substances that are…. ssshhh…ANABOLIC. Indeed, this was not the case 30 years ago. In fact, this was the prime time for research into Anabolics-expecially Anabolic Steroids! While most companies were pouring millions of dollars into new more effective anabolic steroids, one company in Hungary, named Chinoin, decided to look for a non-steroidal compound that would have the positive effects of Anabolics but without the negative characteristics. After over 10 years of research, they discovered Methoxivone. Although developed in the last millennium, it is destined to become one of the best ergogens in this new millennium. Many months ago I talked about a supplement which I named the
“Anabolic Silver Bullet.” Commonly
referred to as Ipriflavone, this dietary nutrient was also produced by
Chinoin of Hungary in the midst of creating their perfect anabolic.
Indeed, in the article on Ipriflavone we saw how it was not only
highly anabolic to both bone and muscle tissue, but how it increased
endurance, lowered cholesterol and decreased the size of fat stores. Furthermore, we looked at the safety of Ipriflavone and
determined that it had no estrogenic activity, no carcenogenic or
teratofenic activity and finally no chronic or acute toxicities. Basically, Ipriflavone looked like the perfect anabolic
compound. Well that was
then and this is now! After
thousands of people have taken this compound and after dozens of anecdotal
reports we now have the ability to make a really good assessment.
Is Ipriflavone worth its salt?
The answer is, “YES!” The
majority of the people taking Ipriflavone do not instantly change their
body type over night but make progress over time.
Unfortunately in the world of quick fixes, people want to feel the
effects of something right away…sometimes even overnight.
Nearly everybody that I know that has taken Ipriflavone in the
proper dosages for at least 6 weeks has made some very significant
improvements. You’re
right though, this article is not about Ipriflavone.
However, it is about another, similar isoflavone, called
Methoxivone. Methoxivone, or
5-methyl, 7-methoxyisoflavone was the end result of Chinoin’s extensive
research on anabolic isoflavones. Said
in another way, Methoxivone is three times more potent than ipriflavone in
term of increasing lean body mass, decreasing adipose stores, increasing
endurance, etc., etc. IF Methoxivone is so great then why didn’t I just come out with
it instead of Ipriflavone over a year ago?
Unfortunately, because Ipriflavone was discovered many years before
Methoxivone, a great deal of developmental work had been done on it.
In fact in several countries Ipriflavone was studied and brought to
the market as an anti-osteoporosis agent (remember that Ipriflavone is
anabolic to bone tissue). Thus,
a few years ago when I started researching these anabolic isoflavones, I
was limited only to Iproflavone because of cost and availability.
Although I was impressed with Ipriflavone I had my sights set on
Methoxivone. My excitement stemmed not only from the published data on
Methoxivone but also based on the plethora of correspondence I had with
Chinoin. According to their
research department, they performed a barrage of experiments to examine
its anabolic potency. To give
an idea of its capabilities, Methoxivone was studied to see whether it
could antagonize the catabolic effects of gluccocorticoids, i.e. cortisol. For those of you who don’t know already, gluccocortidoids are one
of the most catabolic entities (especially relating to proteinaceous
tissue such as muscle) in the human body.
Although they do have some very important beneficial properties
such as anti-inflammation, when it comes to gaining muscle and losing fat
they are your worst nightmare. Gluccocorticoids are always in your body and they are always
wreaking havoc. They are
produced in the adrenal cortex, released into the blood and attach to
various receptors in nearly every tissue in the body.
The problem arises when these corticoids activate catabolic enzymes
such as calpains. Calpains
are proteolytic enzymes that are especially active in muscle tissue and
are a key component in the process of muscle turnover.
In simple terms, the more gluccocorticoids you have the more
proteolytic enzymes like calpains you have and consequently the less
muscle tissue you will have. Unfortunately,
the catabolic effects of gluccocorticoids are very difficult to antagonize
and very few compounds have been shown to do this effectively. As if it were a surprise, anabolic steroids just happen to be
the overall best agents to defeat the seemingly almighty coricoids.
The only problem is that anabolic steroids are not always the best
compounds to work with because of various negative side effects. Whoops! There I go
getting side tracked again! I
know this article is about Methoxivone and not cortisol so I’ll try to
stay on the right subject matter. First,
though let me explain that Chinoin tested Ipriflavones in earlier studies
against gluccocorticoids. Although
Ipriflavone helped to reduce slightly the effects of cortisol, there was
no strong inhibition. Methoxivone,
on the other hand, almost completely antagonized cortisol’s effects at
lower dosages and did a good job of attenuating them at higher dosages. Now that we know Methoxivone works, just exactly how is it
producing its magic? I
wouldn’t be all that surprised if, like anabolic steroids, it works on
multiple pathways. However,
at this time we have only elucidated one mechanism through which
Methoxivone works. Remember
those nasty little enzymes called calpains?
Interestingly, it seems that anabolic isoflavones, especially
Methoxivone, modulate or reduce these to some degree.
With calpains wreaking less havoc on your muscle tissue, a net
anabolic (actually anti-catabolic) response is achieved.
This makes sense, especially when you think about the fact that
Methoxivone antagonizes the effects of gluccocorticoids so strongly.
Simply speaking it puts a monkey wrench in cortisol’s machinery. One thing that has always disturbed me is the data given in the
patents on the growth rates of various animals supplemented with either
Ipriflavone or Methoxivone. Although Methoxivone was 3 times more potent than Ipriflavone
according to Chinoin, both isoflavones caused an astonishing percentage
increase in the growth rate. For
a long time, I expected that a 10% increase in growth rate should
translate into a 10% increase in bodyweight for a full-grown person. However, this was faulty thinking since a change in LBM
weight is much harder to affect when an animal is full grown than when it
is growing. Thus, although
the effect of Methoxivone is quite noticeable and satisfying, it won’t
increase your lean body mass by 40 pounds as you might have expected. Another misconception that I would like to clean up is that an
anabolic compound will cause a person to gain weight.
Actually this is far from the truth.
Actually an anabolic or anti-catabolic compound is what I like to
call a nutrient partitioning agent. Normally,
when you ingest calories a certain portion of them are used for immediate
needs, others are partitioned off into fat stores, and still others are
used to build proteinaceous tissues.
A nutrient partitioning agent will take more of those calories and
shuttle them into proteinaceous tissues.
Therefore, a nutrient partitioning agent or anabolic compound will
make you leaner and more muscular if your calorie intake remains the same
but it won’t cause you to gain weight.
To gain weight you must either consume more calories or slow down
your metabolism. The great thing about taking an anabolic is that if you
ingest more calories, it will cause a preferential increase in muscle
mass. We see this point
perfectly demonstrated in people taking anabolic steroids.
If they eat an extra calorie, they will gain weight with a good
proportion of this being as lean body mass.
If they diet and eat less calories than normal they will obviously
lose weight; however more muscle tissue will be preserved and more adipose
tissue lost than normal. Methoxivone
is no exception to this rule. I
have seen it literally do wonders for those people who have an eating
habit which supports their goals. Women,
who tend to eat a modest amount of calories, tend to lean out
significantly and become very fit looking.
I have seen men, on the other hand, either gain large amounts of
lean body mass or lose considerable amounts of body fat—again depending
on their calorie intake. The last thing I want to discus are safety and recommendations.
In terms of safety, Methoxivone should be just as safe as
Ipriflavone (which is unusually safe for men, women, and even children).
Like Ipriflavone, Chinoin performed many studies on multiple animal
types which demonstrated its high margin of safety—in both acute and
chronic situations. As with
other anabolic isoflavones, Methoxivone has the potent ability to increase
endurance, lower cholesterol and improve overall health and well being. An effective dose of Methoxivone is 200mg-400mg taken 2-3 times per
day. The only catch with this
is bioavailability. Unfortunately, without an effective system, Methoxivone is
not well absorbed and therefore could be rendered ineffective.
Please be sure that any isoflavone product you purchase has a
scientifically sound method to drastically increase its bioavailability.
Finally, be careful with liquid formulations of this product.
I have been witness to a few shoddy internet companies which sell
purported Methoxivone products in some suspicious liquid carrier.
These products are not only difficult to consume but could
potentially be very harmful. Several
of these products have been tested and they contained only half of the
amount of Methoxivone that was listed on the label.
Talk has it that the Methoxivone is being oxidized and broken down
into potentially dangerous compounds, as the saying goes, “Buyer
Beware!” In the first part of this millennium you will see sports nutrition
technology make absolutely gigantic strides.
I am personally working on about a dozen novel compounds that will
be highly effective ergogens. In
the meantime, enjoy Methoxivone and enjoy the new millennium! |
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